Effects of Bispectralindex -onclosedloop -target controlled infusion with propofolsedation onbiochemical indexesof patients with intracranial craniocerebraltrauma

doi:10.3969/j.issn.1002-1949.2015.05.012

Abstract：Objective In this study, we investigated the method ofBIS monitor bispectral index-onclosed loop -target controlled infusion with propofol sedation.We aims to analyze the biochemical indexes changes of patients with intracranial craniocerebral trauma in differentBIS values feedback control sedation, trying to find the most suitable BIS value of sedation therapy for brain trauma patients.Methods Sixty cases of patients with craniocerebral trauma admitted to EICU, the First Affiliated Hospital of Kunming Medical University, were randomly divided into four groups (15 cases in each group) .Three groups with different BIS values (55~65 inⅠgroup, 65~75 inⅡ group, 75~85 inⅢgroup) as a feedback control condition, the closed-loop target controlled infusion using propofol sedation;GroupⅣadopted micro-pump infusion of propofol sedation as controls in accordance with the patient's condition.Brain microdialysiswas sampled on the first hour after the sedation, and after that it was collected every 8huntil 48 h after sedation.Microdialysis from the hemorrhage surrounding swelling brain tissue was collected to measure glucose dialysate ( Glu ) , lactate ( Lac ) and glycerol ( Gly ) concentration.Results SLD-t test showed that Glu, Lac, Gly concentrations,between any two groups were significantly different ( P <0.001 ) .Conclusion BIS feedback control loop target controlled infusion system, and propofol sedation have different effects on biochemical indexes of patients with intracranial craniocerebraltrauma, when BIS value is in 55 ~65 there is a good protect effect for the brain, but when BIS value is in 55~65 whether sedation therapy is optimalis unclear, the side effects needsto be further identified.