Diagnostic value and clinical significance of Scys C and Ucys C in critically ill patients with acute kidney injury
ZHAO Juan
BIAN Yu-Yao
Abstract：Objective To investigate the level of serum cystatin C ( Scys C) and urine cystatin C (Ucys C) in critically ill patients with acute kidney injury (AKI).Methods One hundred and Forty-one critically ill patients admitted in China Petroleum Central Hospital ICU from May 2013 to May 2014 were included.Thirty-two patients with AKI were included as AKI group, and109 non-AKI patients as a control group.Scys C and Ucys C were measured and compared between these two groups.Spearman’s correlation analysis was performed to analyze the correlation among Scys C, Ucys C, and Scr, APACHEⅡscore.ROC was drawn and the area under ROC curve was calculated.The value of cystation C ( Cys C) in diagnosing was analyzed.The diagnostic value about Scys C and Ucys C was determined by the elevated rates of Scys C and Ucys C.Results ①The differences of Scys C, Ucys C, Scr and APACHEⅡscores between AKI group and non-AKI group were statistically significant ( P<0.05).②Spearman’s correlation analysis showed no correlation between Scys C and Ucys C ( P >0.05).③The area under the curve of Scys C and Ucys C were 0.848 and 0.810, respectively in ROC curve of critically ill patients with AKI.④Chi square test showed that increase rate of Scys C and the UcysC had no significant difference of AKI patients (P>0.05).Conclusion CysC can be used as a diagnostic indicator of severe patients with AKI.There is no statistical difference if Scys C and Ucys C are set up as diagnostic indicators in patients with severe AKI.
Keywords：Cystatin CAcute kidney injury ( AKI)Critical illness
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 415-417 )