Effect of oxygen flow rate during oxygen-drived heparin inhalation on the arterial blood gas and coagulation function in mechanically ventilated AECOPD patients
Abstract：Objective To investigate the effects of different amount oxygen-drived inhalation of heparin on arterial blood gas and coagulation function in mechanically ventilated patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD) .Methods Fifty-one patients with AECOPD mechanical ventilation were randomly divided into A, B, C three groups.Group A (17 cases) were given the oxygen flow rate of 5 L/min atomizing inhalation, group B (19 cases) were given the oxygen flow rate of 7 L/min, group C (15 cases) were given the oxygen flow rate of 9 L/min.Arterial blood gas and coagulation function were detected before and after atomizing inhalation (30 min, 1, 3, 7 days) in all patients.Results Compared with group A and C, Patients in group B had obviously improved arterial blood gas and were statistically significant (P<0.05), and there was no no statistical significant difference between group A and group C( P >0.05).Compared with before atomization, Patients in group B had significantly improved arterial blood gas at each time point after inhalation ( P<0.05);Patients in group A only showed improved arterial blood gas 30 min after inhalation ( P<0.05);but there was no improvement on all time points in group C (P>0.05).Seven days after inhalation, prothrombin time ( PT) , activated partial thromboplastin time ( APTT) and fibrinogen ( FIB) were not significantly different from the level before inhalation in all three groups (P>0.05).Conclusion The best oxygen flow rate is 7 L/min for heparin inhalation in mechanically ventilated patients with AECOPD.It significantly improves the arterial partial pressure of oxygen, reducing carbon dioxide partial pressure, but has less influence on the coagulation function.
Keywords：Atomization inhalationHeparinChronic obstructive pulmonary disease ( COPD)Arterial blood analysisCoagulation function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 411-414 )