Effect of thymosinα1 on Th17 cells in septic rats
Abstract：Objective To investigate the effect of thymosin α1 on Th17 cells in rats with sepsis.Methods We observed the effect of thymosin α1 on mortality, Th17 cells, IL-17, albumin and C-reactive protein (CRP) in reforming cecal ligation and puncture (CLP) induced septic rats. Results The decreased cumulative 7 -day mortality in septic mice was alleviated by Thymosin α1. Concentration of Th17 cells and IL -17 in CLP -induced septic rats was increased significantly compared to control group.Thymosinα1 significantly decreased Th17 cells and IL-17 concentration in CLP-induced septic rats.Plasma albumin level was decreased in septic mice and the level of plasma albumin was elevated by Thymosinα1.Concentration of CRP increased in both sepsis groups, but was less prominently in thymosin α1 treated group.Conclusion Thymosin α1 can improve immunological function, inflammation condition and protein metabolism through Th17 cells and IL-17.
Keywords：Thymosinα1SepsisTh17 cellsC-reactive protein( CRP)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 398-401 )