Predictive value of plasma cardiac troponin I, N-terminal-pro-brain natriuretic peptide and APACHEⅡscore in elderly patients with septic shock
Abstract：Objective To investigate the predictive value of biochemical markers with myocardial injury and plasma N-terminal-pro-brain natriuretic peptide ( NT-proBNP) in patients with elderly sepsis patients.Methods A total of 61 intensive care unit ( ICU) elderly patients with sepsis shock were enrolled from January 2012 to May 2013, general information were collected.Blood gas analysis, blood biochemistry, cardiac troponin I ( cTnI ) , CK -MB, plasma NT -proBNP concentration were collected within 24 hours of admission.The enrolled patients were divided into the survival group and death group according to 28 -day mortality.The blood lactate ( Lac ) , creatinine ( CRE) , cTnI, CK -MB and NT -proBNP levels in two groups were compared, and the predictive value of the indicators were analyzed with receiver operating characteristic ( ROC) curve.Results①CK-MB, Lac, CRE, NT-proBNP, APACHEⅡlevels in the death group were significantly higher than those in the survival group (P<0.01).②The ROC curve that prognostic indicators forecast 28 days shows, APACHEⅡAUC =0.924, the cut-off point value (cut-off) predict prognosis is 22.5 with a sensitivity of 90.0%and specificity of 81.0%.NT-proBNPAUC =0.869, the cut-off point value is 1256 ng/L with a sensitivity of 92.5%, specificity of 81.0%.The remaining area under the curve of each index were lower than NT-proBNP, CREAUC =0.835, LacAUC =0.731, CK-MBAUC =0.711. Conclusion cTnI, NT-proBNP and APACHEⅡare independent prognostic factors to predict elderly patients with septic shock.
Keywords：N-terminal-pro-brain natriuretic peptideCardiac troponin I( cTnI)Septic shockPrognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 297-300 )