Prognosis analysis of abciximab combined with low molecular heparin in treatment of ischemia postconditioning after acute myocardial infarction

WANG Dao-hai

doi:10.3969/j.issn.1002-1949.2015.03.014

Abstract：Objective To analyze the abciximab combined with low molecular weight heparin in the treatment of ischemic postconditioning after acute myocardial infarction ( AMI) the clinical efficacy and safety.Methods A total of 772 ischemic postconditioning AMI patients from April 2011 to April 2014 were included in this study.The patients were divided into observation group ( n =428 ) and control group ( n=344 ): the observation group received abciximab plus low molecular weight heparin therapy, the control group only received low molecular weight heparin therapy;comparison of 12 hours the re-passing the rate of blood vessels between two groups of patients, and the serum creatine kinase (CK), creatine kinase isoenzyme(CK-MB), left ventricular end diastolic volume index(LVEDVI), left ventricular end systolic volume index(LVESVI)and left ventricular ejection fraction(LVEF)index 3 months after treatment and cardiac events within 3 months.Results The level of CK, CK -MB, LVEDVI, LVESVI were significantly decreased in the two groups after treatment, and the level of LVEF was singificantly increased ( P <0.05), the observation group improvement was more obvious than control group ( P <0.05 ) .296 cases in observation group were of vascular recanalization, with a recanalization rate of 69.2%, but only 95 cases in control group 95 cases were of recanalization, with a recanalization rat of 27.6%, the recanalization rate was significantly higher than that in control group. 145 patients in the observation group and 254 cases in control group occurred cardiac events, with a cardiac events incidence of 33.9% and 73.8%, respectively; the incidence of cardiac events was significantly lower in the observation group than that in the control group.Conclusion Abciximab combined with low molecular weight heparin can effectively improve cardiac function, reduce the incidence of cardiac events.It is of positive significance to the prognosis and the improvement of the quality of life, worthy of further study.