Prognostic value of plasma soluble receptor for advanced glycation end products and APACHEⅡscore for patients with sepsis
Abstract：Objective This study aims to investigate significance of plasma soluble receptor for advanced glycation end products ( sRAGE ) and acute physiology and chronic health evaluationⅡ( APACHEⅡ) in evaluating and predicting prognosis in sepsis.Methods Seventy -nine sepsis patients were collected in our hospital ICU from February 2013 to August 2014.The dynamic changes of plasma sRAGE were tested on the 1st, 3rd day.At the same time APACHEⅡscore were recorded.The patients were divided into survival group and non-survival group according to 28 day mortality, and to analyze its difference and correlation with plasma sRAGE and APACHEⅡ score.Finally, the positive predictive value of two biomarkers was assessed.Results The plasma sRAGE level and APACHEⅡscore of survival group were lower than those of non-survival group on the 1st, 3rd day (P<0.05);On the same day, the plasma sRAGE level and APACHEⅡ score was positively correlated ( r=0.74, P<0.05;r=0.61, P<0.05).On the 1st day, the plasma sRAGE level and APACHEⅡ score area under the ROC curve were 0.93 and 0.86 (P<0.05), respectively; On 3rd day, the plasma sRAGE level and APACHEⅡscore area under the ROC curve were 0.75 and 0.69 (P<0.05), respectively. Conclusion The plasma sRAGE level is obviously correlated with the APACHEⅡscore in patients with sepsis.The plasma sRAGE level may be used as a critical parameter in predicting the prognosis of sepsis.
Keywords：Soluble receptor for advanced glycation end products( sRAGE)Acute physiology and chronic health evaluationⅡ( APACHEⅡ)SepsisPrognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 207-210 )