Therapeutic effects of Polyethylene glycol 4000 on the early intestinal injury in rats secondary to traumatic shock
Abstract：Objective To investigate the therapeutic effects of Polyethylene glycol 4000 ( PEG4000) on the early intestinal injury secondary to traumatic shock in rats and explore its possible mechanisms.Methods Forty SD rats were randomly divided into four groups: control group, shock group, conventional intravenous resuscitation ( CIR ) group and drag reducing polymers group ( DRP group, IV 50 μg PEG4000).The rats in the four groups were sacrificed two hours after resuscitation. The levels of intercellular cell adhesion molecule -1 ( ICAM -1 ) , malondialdehyde ( MDA ) , superoxide dismuctase ( SOD ) and the activity of diamine oxidase ( DAO ) in the intestinal tissue, plasma levels of D-lactate ( D-LA) and tumor necrosis fator-α( TNF-α) of rats were detected. Grading of the intestinal mucosal damage ( GIMD) and intestinal wet/dry ( W/D) weight ratios were measured.Results Compared with those in the CIR group, the levels of ICAM -1, MDA in the intestinal tissue, plasma D-LA, TNF-α, GIMD and intestinal W/D ratios of rats in DRP group were decreased significantly, while the levels of SOD and the activity of DAO in the intestine tissue were increased significantly ( all P <0.05).Conclusion PEG4000 can significantly mitigate the early intestinal injury secondary to traumatic shock, and its mechanism may be associated with inhibiting the expressions of ICAM-1 and TNF-α, scavenging free radicals and anti-lipid peroxidation.
Keywords：Traumatic shockPolyethylene glycol 4000 (PEG4000)Secondary intestinal injuryIntercellular cell adhesion molecule-1 (ICAM-1)Tumor necrosis fator-α(TNF-α)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 157-160 )