Serum homocysteine level and methylenetetrahydrofolate reductase gene C677T polymorphism in patients with hypertension

doi:10.3969/j.issn.1002-1949.2015.02.014

Abstract：Objective To explore the relationship between serum homocysteine ( HCY) level, methylenetetrahydrofolate reductase ( MTHFR) gene C677T polymorphism and primary hypertension. Methods We collected 230 primary hypertension patients from the Cardiovascular Department of Shenzhen No.2 People's Hospital outpatient and ward who were 20 ~78 years old; and 200 healthy subjects as control group from the Medical Department of Shenzhen No.2 People's Hospital.The serum HCY level, MTHFR genotype C677T polymorphismand other related indicators were determined in hypertensive patients and healthy subjects.Results Compared with the control group, the serum HCY level of the hypertension group was higher than that of the healthy subjects, the difference was statistically significant (P <0.05).Compared with the control group, the ratio of MTHFR genotype C677T locus in heterozygous type and mutant in the hypertension group was higher than the latter, the difference was statistically significant ( P <0.05 ).In grade 2 and grade 3 hypertension patient subgroups heterozygous type and mutant ratio was higher than that of grade 1 hypertension group, the difference was statistically significant (P <0.05).Conclusion Serum HCY levels are elevated in patients with hypertension, and the MTHFR genotype in C677T heterozygous and mutant ratio are also increased significantly,especially in severe hypertension group.Serum HCY level and the gene type of MTHFR C677T site have certain effect on hypertension.