Clinical study of using vecuronium treat patients with abdominal compartment syndrome
Abstract：Objective To investigate the clinical value of using vecuronium treat patients with abdominal compartment syndrome and the factors that affect prognosis.Methods Forty cases with abdominal compartment syndrome in the ICU were randomly divided into treatment group (20 cases) and control group (20 cases).Patients in control group were treated by anti -infection, gastrointestinal decompression, sedation, prokinetic drugs, mechanical ventilation, blood purification, surgery and other conventional treatment. Based on the above treatment, treatment group using muscular blockers vecuronium intermittent intravenous infusion or continuous micro -pump.Dynamic change of intra -abdominal pressure, abdominal perfusion pressure, blood pressure, blood lactate, urine output, oxygenation index, C-reactive protein levels, APACHEⅡ score were determined, and ICU stay and hospital mortality were recorded and compared between the two groups.Results For patients with abdominal compartment syndrome vecuronium can not only effectively lower abdominal pressure, abdominal perfusion pressure, blood lactate (P<0.05), but also improve arterial oxygenation index ( P<0.05 ) .However, no significant effect of vecuronium was shown on ICU stay and hospital mortality.Conclusion Vecuronium significantly improves the intra-abdominal pressure and delays the progress of the disease in the short term in patients with abdominal compartment syndrome, but does not affect the overall prognosis.
Keywords：VecuroniumAbdominal compartment syndrome( ACS)Abdominal pressureNeuromuscular blocking agent( NMB)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 122-125 )