Effects of meloxicam on the changes of COX-2 and PPAR-γmRNA in lung of rabbits with acute lung injury induced by endotoxin
WENG Cui-lian
WANG Jian-xin
QU Yue-jin
Abstract：Objective To investigate the effects of meloxicam on the changes of cyclooxygenase -2(COX-2) and peroxisome proliferation activated receptor -γ(PPAR-γ)mRNA in lung of rabbits with acute lung injury (ALI) induced by endotoxin (ET) and to explore it′s protective mechanism .Methods Twenty four Japanese flap -eared white rabbits were randomly assigned to three groups:control group (A group), ET -treated group(B group) and meloxicam for treatment group (C group).Rabbit ALI models were replicated with intravascular ET injection (700 μg/kg weight), meloxicam (2.5 mg/kg weight) was intravascularly injected as treatment group.During the experiment, arterial blood gases were measured.The pathologic changes were examined with light microscope .We measured COX -2 and PPAR -γmRNA in every group .Results COX -2 mRNA expression in B group was significantly higher than that in A group (P<0.01),and COX-2 mRNA expression in C group was significantly lower than in B group (P<0.01).PPAR-γmRNA expression in B group was significantly lower than that in A group (P<0.01),and PPAR-γmRNA expression in C group was significantly higher than in B group (P<0.01).Conclusion Meloxicam can down -regulate COX-2 and up-regulate PPAR-γexpression , which posseses protective effects on ALI in rabbits induced by ET .
Keywords：Acute lung injury(ALI)Cyclooxygenase-2(COX-2)Peroxisome proliferation activated receptor -γ( PPAR-γ)Meloxicam
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1119-1122 )