Myocardial protective effect of dexmedetomidine on cardiopulmonary bypass in patients with mitral valve replacement
JIN Li-min
ZHANG Yan-bing
LI Jian
Abstract：Objective To observe the protective effect of dexmedetomidine ( DEX ) on myocardium in patients with mitral valve replacement .Methods The selected patients were randomly divided into two groups:group DEX (group D, 25 cases) and saline group (group C, 23 cases).D group was given DEX load (0.5 g/kg, l0 min injection pump), start induction of anesthesia after pump, and 0.5 g/( kg· h) DEX until the end of operation .Group C used saline the same way pumping capacity.Heart rate (HR), mean arterial pressure (MAP) of the two groups were recorded at 5 time points:before induction of anesthesia (T0), after induction of anesthesia, before skin incision (T1), the beginning of cardiopulmonary bypass ( T2 ) , at the end of CPB ( T3 ) , 6 h after operation ( T4 ) . Blood samples were collected for determination of serum troponin I ( cTnI ) and ischemia modified albumin (IMA) in the T1, T3, T4, 12 h after operation (T5), 24 h after operation (T6) 5 time points.Operation time, cardiopulmonary bypass time, aortic blocking time, postoperative hospitalization time, automatic rebeating rate and other clinical indicators between the two groups were also recorded . Results MAP in group D before skin incision ( T1 ) , the beginning of cardiopulmonary bypass ( T2 ) while was higher than that in group C , the difference was statistically significant ( P<0.05 ) .HR in group D before skin incision ( T1 ) , the beginning of cardiopulmonary bypass ( T2 ) was significantly lower than that in C group, the difference was statistically significant (P<0.05).The cTnI levels of D group at the end of CPB ( T3 ) , 6 h after operation ( T4 ) , 12 h ( T5 ) , 24 h ( T6 ) were significantly lower than those in C group, the difference was statistically significant (P<0.05).IMA of group D at the end of CPB ( T3 ) , 6 h after operation ( T4 ) was significantly lower than that in C group , the difference was statistically significant (P<0.05).Automatic rebeating rate in D group was significantly higher than that of C group , the difference was statistically significant ( P <0 .05 ) .Conclusion Dexmedetomidine can stabilize the hemodynamics , reduce myocardial injury during perioperative period in patients with mitral valve replacement , has certain protective effect on myocardial .
Keywords：DexmedetomidineExtracorporeal circulationMitral valve replacementMyocardial protection
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1090-1093 )