Prognostic value of procalcitonin in patients with septic shock

doi:10.3969/j.issn.1002-1949.2014.12.003

Abstract：Objective The present study aims to evaluatethe prognostic value of peripheral blood procalcitonin ( PCT ) in ICU patients with septic shock .Methods This retrospective analysis consist of 102 cases of septic shock patients from January 2012 to January 2013 in the intensive care unit of the Second Affiliated Hospital of Harbin Medical University . Peripheral blood PCT levels were continuously determined on admission 1,2,3,4,5 day.The patients were divided into survival group and death group according to 28 d survival.PCT levels, APACHEⅡ score and SOFA score were compared and the correlations were analyzed between the two groups . Results There were no significant differences of PCT on admission 1 d, 2 d and 3 d between survival group and death group , but PCT of the death group on admission 4 d and 5 d were significantly higher than the survival group (P<0.05). Lactic acid, SOFA score and APACHEⅡscore of the death group were significantly higher than those of the survival group(P<0.05).PCT levels in patients on admission 4 d and 5 d were positively correlated with SOFA score and APACHEⅡscore (R were 0.389 and 0.393 on admission 4 d;R were 0.649 and 0.658 on admission 5 d;P<0.01).PCT was 2.0μg/L when the sensitivity was 81.2%and specificity of 72.8%.Conclusion Dynamic monitoring PCT levels can effectively assess the prognosis of patients with septic shock .