Comparison of the therapeutic effect between sustained low -efficiency dialysis combined hemoperfusion and continuous blood purification in patients with septic acute kidney injury
Abstract：Ob jective To compare the therapeutic effect between sustained low -efficiency dialysis (SLED) combined hemoperfusion (HP) and continuous blood purification (CBP) in patients with septic acute kidney injury ( AKI) .Methods Fifty-two patients during January 2010 and January 2013 with septic AKI were randomly assigned to receive SLED combined HP group ( n=25 ) and CBP group ( n =27 ) according to the different treatment ways . The mean arterial pressure ( MAP ) , oxygenation index (OI), serum creatinine (Scr), tumor necrosis factor-α(TNF-α), interleukin-6 ( IL-6) and acute physiology and chronic health evaluationⅡ ( APACHEⅡ) score, ICU stay, 90-day mortality were compared before and after treatment of two groups .Results The levels of Scr , TNF-α, IL-6, APACHEⅡ score after treatment of 2, 3, 7 -day decreased significantly in SLED combined HP group compared with CBP group (P<0.05), but OI and MAP increased significantly (P<0.05).There were significant differences in ICU stay between two groups (P<0.05), but there were no significant differences in 90 -day mortality between two groups ( P>0.05 ) .Conclusion SLED combined HP treatment may be superior to CBP treatment in clearing toxins and inflammatory mediators, and can shorten the ICU stay , but may not be superior to CBP in improving clinical outcomes.
Keywords：Sustained low-efficiency dialysisContinuous blood purificationHemoperfusionInflammatory mediatorsSepsisAcute kidney injury
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1061-1063,1064 )