Association betweenα2-Heremans-Schimid glycoprotein (AHSG) polymorphism and cerebral infarction

doi:10.3969/j.issn.1002-1949.2014.11.015

Abstract：Objective To investigate the relationship between five single -nucleotide polymorphism (SNP) ofα2-Heremans-Schimid glycoprotein (AHSG) and cerebral infarction(CI). Methods Five gene polymorphisms were detected for 200 patients of CI and 100 healthy controls using direct sequencing method.The χ2 test was adopted to check the difference in genotype and allele frequency distribution between the cases and the controls, the accordance with Hardy-Weinberg equilibrium in the group, and genotype and allele risk rate were showed with odds ratio ( OR) .Results There were no significant differences(χ2 =5.243,P=0.079) between CI and healthy control in CC, CT, TT genotypes of rs4917 of AHSG gene.The frequency of CC genotype in CI group was significantly higher than in the control group(χ2 =5.230,P=0.027).And the diseased risk of CI in genotype CC was higher than CT+TT (OR=1.758,95%CI 1.082~2.856).The frequency of C allele between CI and healthy control had significant differences (χ2 =4.758,P=0.032,OR=1.492,95%CI 1.040~2.139) .The frequencies of CC, CG, GG of rs4018 of AHSG gene had significant difference between two groups(χ2 =7.335,P=0.024).Compared with genotype CG+CC, the frequency of genotype GG in CI was higher than in the control group(χ2 =5.055,P=0.028) .And the diseased risk of CI in genotype GG was higher than CG+CC (OR=2.965,95%CI 1.106 ~7.953).The frequency of G allele in CI was higher than in the control group, which had no significant differences(χ2 =0.408,P=0.566) .The frequencies of CC, AC, AA of 1071592 of AHSG gene had no significant difference between two groups(χ2 =5.375,P=0.065).Compared with genotype AC +CC, the frequency of genotype AA in CI was significantly higher than in the control group(χ2 =4.615,P=0.037), and the diseased risk of CI in genotype AA was higher than AC+CC (OR=3.593,95%CI 1.041~12.394). The frequency of A allele in CI was higher than in the control group, but which had no significant differences (χ2 =0.942,P=0.351,OR=1.229,95%CI 0.810 ~1.864).There were no significant differences among rs2070633、rs2070635 between two groups. Conclusion AHSG gene rs4917 genotype CC and C allele, rs4918 genotype GG, rs1071592 genotype AA might be a risk factor for increasing the diseased rate of cerebral infarction in population, which rs4917 C allele might be predisposing genes for cerebral infarction.