Variation and influencing factors of Lp-PLA2 and HCY levels in acute ischemic stroke patients

YAN Jing; XU Tie

doi:10.3969/j.issn.1002-1949.2014.11.008

Abstract：Objective To investigate the variation and influence factors of plasma lipoprotein-associated phospholipase A2 ( Lp-PLA2 ) and homocysteine ( HCY) in the patients with acute ischemic cerebral stroke.Methods One hundred and ninety-two cases with acute ischemic cerebral stroke as stroke group, according to National Institutes of Health Stroke Scale, were divided into mild group ( n=16), moderate group (n=163), and severe group (n=13).Seventy-nine cases of healthy donors were selected at the same time as control.Enzyme -linked immunosorbent assay ( ELISA ) was performed to detect plasma Lp-PLA2 , chemiluminescence was carried out for plasma HCY, besides we detect the white blood cells ( WBC ) , neutrophil ( NE ) and blood biochemical analysis.Results (1) Plasma levels of Lp -PLA2 and HCY of stroke group were significantly higher than those of the control group, and severe group were higher than the moderate group which were higher than the mild group, the differences were all statistically significant (P<0.05).(2) Stroke group showed markedly higher white blood cells ( WBC) , neutrophil ( NE) , cholesterol ( TC) , triglyceride ( TG) , low density lipoprotein ( LDL) , lipoprotein Lp ( a) and glucose ( Glu) levels compared with the control group, the difference was statistically significant ( P<0.05 ); high density lipoprotein ( HDL) was lower in the stroke group than that of the control group, the difference was statistically significant (P <0.05). (3) Multiple linear regression analysis showed that ①Lp -PLA2 was positively correlated with age, obesity, NIHSS, HCY, had no correlation with gender, smoking, diabetes, high blood pressure, blood lipids;②HCY was positively correlated with gender, smoke, NIHSS and LP ( a ) .Conclusion Lp-PLA2 and HCY were all increased in acute ischemic stroke, and they had a significant correlation, combined detection can provide some help for the clinic treatment and secondary prevention.