Protective effect of Glucocort icoid on intestinal mucosal barrier of septic rats
LIU Mei
LIU Jie
FAN Xue-peng
Abstract：Objective To study the protective effects of Glucocorticoid on intestinal mucosal barrier of septic rats.Sixty-five SD rats were divided into three groups randomly, sham group (n=5), sepsis group (n=30) and Glucocorticoid group (n=30).Sepsis group and Glucocorticoid group were divided into three subgroups ( n=10 ) respectively according to the different time points ( 24 h, 48 h, 72 h).Sham group injected nothing.Sepsis model of rats was replicated by intravenous administration of LPS in sepsis group and Glucocorticoid group.In Glucocorticoid group,the animals were intravenous injected 6 mg/kg of hydrocortisone, and sepsis group received an injection of same amount of saline . Plasma DOA and D-lactate level were detected at every time point .Mortality was compared in three groups.Results Plasma DOA and D -lactate level in sepsis group and Glucocorticoid group were significantly higher than those in sham group at every time point.Plasma DOA and D-lactate level in Glucocorticoid group were significantly lower than those in sepsis group .Mortality in sepsis group at 72 h was obviously higher than that in sham group and had no difference with that in Glucocorticoid group. Conclusion Glucocorticoid can reduce levels of inflammatory factors in septic rats and may have protective effects on the cells and organs of septic rats.
Keywords：GlucocorticoidSeptic shockRatsIntestinal barrierDiamin oxioles ( DOA)D-lactate
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 982-984 )