The relationship between with toxic encephalopathy induced by genetic polymorphism of metabolic enzymes
Abstract：Objective Whether genetic polymorphisms of enzymes related to metabolism of organic solvent will affect the prevalence rate of human solvent encephalopathy (CSE).Methods The present study included patients with CSE (n=97) and control individuals (n=214) which had similar social and economic background .The gene polymorphism of metabolic enzymes and organic solvent in two groups were observed .The method of restriction fragment length polymorphism ( RFLP) was used to detect the genes polymorphism including CYP1A1 (MspI and Ile/Val), CYP2E (RsaI and DraI), EPHX1 (exon Tyr113His and exon 4 His139Arg 3), GSTM1 (null genotype), GSTT1 (missing gene) and GSTP1 (GSTP1*A, GSTP1*B and GSTP1*C alleles).Results CYP2E1*5B the mutant allele (OR 5.8, 95%CI 1.8~18.8) and GSTP1*C gene mutation (OR 0.40, 95%CI 0.17~0.94) CSE correlated to a higher incidence of CSE .But EPHX1 exon 4 Arg139 mutation allele homozygous was related to low risk of CSE (OR 0.25, 95%CI 0.06~1.13).Conclusion This study suggests that CYP2E1, EPHX1 and GSTP1 genetic polymorphisms may change the risk of CSE .
Keywords：Chronic solvent encephalopathy ( CSE)PolymorphismGenetic
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 919-923 )