Clinical study on the changes of lung specific protein-CC16 after lung contusion

doi:10.3969/j.issn.1002-1949.2014.10.012

Abstract：Objective To explore the clinical value of continuously monitoring serum CC 16 levels in diagnosing pulmonary contusion , estimating its severity degree and predicting disease progression.Methods Thirty -one acute trauma patients with lung contusion diagnosed by chest computed tomography were included , and reexamined chest CT on day 3, 5 and 7 after injury.Total contusion volume was calculated by the Siemens syngo volume calculation program .Complications like pleural effusion or atelectasis were observed and recorded .Enzyme-linked immunoassay ( ELISA) was employed for measuring the levels of CC 16 in all patients for seven days , another 15 serum were taken from healthy volunteers to provide the reference value .Correlation analysis was further conducted for the CC16 levels and pulmonary contusion volume and its variations .Results Serum concentrations of CC 16 in all lung contusion patients were significantly higher than those in controls , and reached a peak value on the first day , but contusion damage area shown in CT gradually increased with the occurrence of atelectasis and pleural effusion .Maximum volume of lung contusion had a positive correlation to the initial and the average concentrations of CC 16, changes in contusion volume were positively correlated with the initial concentration .Conclusion The increased concentration of CC 16 after lung contusion have important reference for diagnosis , and may portend the the possibility of further progress , continuously monitoring CC 16 serum levels in patients may provide the basis for clinical decision -making .