The effects of intralipid on the myocardial dysfunction in septic rats

MENG Xin-ke; FENG Yong-wen

doi:10.3969/j.issn.1002-1949.2014.10.003

Abstract：Objective To investigate the effects of intralipid on the myocardial dysfunction in septic rats.Methods Forty-six Wistar rats were divided into three groups randomly:group A ( sham group, n=8);group B (sepsis group, n=18) and group C (intralipid group, n=18).In group A, appendix exploration was done .In group B & C, the animals received cecal ligation and puncture (CLP).In group A & B, the animals were intravenous dropped saline of 18.6 mL/kg; group C was intravenous dropped intralipid of 18.6 ml/kg after the operation immediately .The left ventricular systolic peak pressure ( LVSP ) , the largest increased rate of left ventricular pressure ( +dp/dt max ) , and maximal negative change infilling pressure versus time (-dp/dt max) at 3 h, 6 h, 12 h and 24 h were measured in three groups .Chondriosome structure of myocardial was observed under Electron microscopy after 24 h in three groups.Res ults LVSP in group B were significantly lower than those in group A at 3 h, 6 h, 12 h and 24 h (P<0.01).LVSP in group C were significantly lower than those in group A at 3 h, 6 h and 12 h (P<0.01) and were statistically lower than that in group A at 24 h (P<0.05). LVSP in group C were significantly higher than those in group A at 3 h, 6 h, 12 h and 24 h ( P<0.01 ) .+dp/dt max and -dp/dt max in group B and group C were significantly lower than those in group A at 3 h, 6 h, 12 h and 24 h.However, +dp/dt max and -dp/dt max in group C were significantly higher than those in group B at 3 h,6 h, 12 h and 24 h .Chondriosome structure of myocardial under Electron microscopy in group C was better than that in group B .Conclusion The cardiomyocytes have been damaged at the early stage of septic rat .Intralipid can improve myocardial function significantly , and may have a certain protective effect on the chondriosome of myocardial .