Effect of high volume hemofiltration on intestinal barrier function in patients with severe sepsis
Abstract：Objective Tto evaluate the change in intestinal barrier function in patients with severe sepsis during HVHF therapy .Methods Fifty -four patients were randomly divided into the control group ( n =31 ) and the HVHF group ( n =23 ) .Peripheral blood from sepsis patients were routinely collected on day 0, 2, 3, 7 after admission.The levels of IFABP, DAO and D-lactate were measured, and death rate of patients in 28 days were recorded.Results There was no difference between the two groups at baseline .However , compared with the conventional treatment group , the plasma levels of IFABP , DAO and D-lactate of HVHF group after HVHF were significantly decreased except for IFABP on day 3 (P<0.05), and the 28-day mortality was significantly reduced (39.1%vs 80.6%, P <0.05).Conclusion HVHF can protect intestinal barrier function, and reduce the mortality as well as improve clinical outcome in elderly patients with sepsis .
Keywords：High volume hemofiltration(HVHF)Severe sepsisIntestinal barrier functionIntestinal fatty acid binding protein(IFABP)Diamine Oxidase(DAO)D-lactate
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 869-872 )