Combined detection of myocardial markers in the early diagnosis of acute myocardial infarction
FENG Dan
CAO Hua-jun
Abstract：Objective To investigate the combined detection of the high sensitive C reactive protein (hs-CRP), cardiac troponin I (cTnI) and creatine kinase isoenzyme (CK-MB) applied in the detection in the early diagnosis of acute myocardial infarction .Methods One hundred and six patients with myocardial infarction admitted to our hospital from January 2010 to December 2013 were included in this retrospective study .Sixty cases of myocardial infarction with typical symptoms were included as the control group .Forty -six cases of myocardial infarction with atypical symptoms were included as the observed group , and these 46 patients finally were confirmed for acute myocardial infarction by invasive or non -invasive examination means .Patients of the two groups were continuously detected for changes of the concentration of hs -CRP, cTnI and CK -MB.The concentrations of hs -CRP, cTnI, CK -MB at different time points were compared between two groups .Results The concentration of CK-MB in both groups started to increase after 3~6 hours of abonormal symptoms , the peak rise at 12~24 hours, and it started to decrease after 3~5 days.The concentration of hs -CRP in both groups started to increase after 3 hours of abnormal symptoms , and remained high levels and started to decrease after 5 days.Compared to the control group , there was no significant difference about the concentrations of CK -MB, hs -CRP, cTnI between the two groups (P >0.05).Conclusion Combined detection of the concentration of CK -MB, hs-CRP, cTnI is helpful to improve the detection of acute myocardial infarction avoiding misdiagnosis , especially in the patients with atypical syndrome .
Keywords：Cardiac markersAcute myocardial infarctionCombined detection
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 840-842 )