Relationship between tumor necrosis factor α-238G/A gene polymorphism and the intermediate syndrome of organophosphorus poisoning
Abstract：Objective To investigate the tumor necrosis factor α( TNFα) gene -238 loci gene single nucleotide polymorphisms ( SNPs ) and the relevance to intermediate syndrome of organophosphorus poisoning . Methods Thirty -six patients with intermediate syndrome of organophosphorus poisoning were detected the TNFαgene -238 SNPs by polymerase chain reaction technology .The data of TNFαSNPs were analyzed between intermediate syndrome of organophosphorus poisoning and acute severe organophosphorus poisoning ( control ) .Results Intermediate syndrome of organophosphorus poisoning group of TNFα-238G/G, G/A and A/A phenotypic frequency were 0.778, 0.104 and 0.028, respectively;the acute severe organophosphate poisoning were 0.940, 0.060 and 0.000 , respectively .Intermediate syndrome of organophosphorus poisoning group of TNFα-238 G, TNFα-238A gene frequency were 0.875, 0.125; the acute severe organophosphate poisoning were 0.970 and 0.030.TNFαgene-238G/A variety of genotype frequencies between intermediate syndrome of organophosphorus poisoning group and acute severe organophosphate poisoning the difference was statistically significant (P<0.05).Conclusion TNFαgene-238G/A polymorphism has correlation with intermediate syndrome of organophosphorus poisoning .
Keywords：Acute severe organophosphate poisoningIntermediate syndrome of organophosphorus poisoningCytokinesGene polymorphism
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 822-824 )