Relationship between the multiple organ dysfunction syndrome and variation of NK cells in patients with major trauma

doi:10.3969/j.issn.1002-1949.2014.09.012

Abstract：Objective To investigate the relationship between the dynamic variation of NK cells and the severe complications in patients with major trauma .Methods According to ISS scores , 42 patients with major trauma were enrolled .At admission and 1, 3, 7 days after injury, peripheral blood were sampled to detect NK cells, and the pulmonary, hepatic, renal and cardiac function were evaluated.Furthermore, the variation of NK cells in the multiple organ dysfunction syndrome ( MODS) group, the inflammatory response syndrome ( SIRS) group and the uncomplicated ( Un) group were analyzed statistically .Results ①Compared with the normal control group , NK cells in the MODS and SIRS groups significantly increased at admission .Compared with the normal control group , NK cells in MODS group significantly increased 1, 3 and 7 days after trauma.Compared with the normal control group, NK cells in the SIRS group significantly increased 1 and 3 days after trauma .NK cells in the Un group recovered to normal level 1 day after trauma .②Compared with the Un group , NK cells significantly increased in the MODS group after trauma .However , NK cells in the SIRS group were higher than that of the Un group only at admission .Conclusion The variation of NK cells are different in different complications after major trauma .Therefore, dynamical monitoring the variation of immune cells maybe play a predictive role for complications after major trauma .Furthermore, the strategy of immune modulating therapies for major trauma should be based on changes of immune cells .