Analysis of influence factor on the prognosis of thrombotic thrombocytopenic purpura
Abstract：Objective To retrospectively analyze 19 cases with thrombotic thrombocytopenic purpura ( TTP) during the past 12 years, and evaluate the relationship between the clinical features , therapy methods and prognosis . Methods In order to understand the influencing factors on the prognosis of the TTP patients , clinical data of 19 patients were analyzed , including the clinical features , therapy methods, hemoglobin, platelet, lactate dehydrogenase (LDH) and indirect bilirubin (IBIL). Results There were different degree of platelet reducing and neurological manifestations .As the disease developing , the hemoglobin decreased .The degrees of fever and renal injure were inconformity .The patients were divided into two groups according the prognosis; the LDH and IBIL of dead group were higher than favourable group in the course of therapy .Fifteen cases received plasma exchange , and survival ratio was 80%.And the glucocorticoid impact treatment had no influence on the prognosis . Conclusion ①The most common features of TTP are platelet reducing and neurological manifestations ,②fractured red blood cells can provide the clue for diagnosis , ③in the therapy course , the changes of LDH and IBIL can indicate prognosis ,④plasma exchange is a effective treatment for TTP , and the high dose glucocorticoid therapy has no influence on prognosis .
Keywords：Thrombotic thrombocytopenic purpuraClinical analysisPrognosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 810-813 )