Research on the relationship between leptin and the pulmonary function in acute exacerabation of chronic obstructive pulmonary disease
Abstract：Objective To explore the relationship between leptin and the pulmonary function in acute exacerabation of chronic obstructive pulmonary disease ( AECOPD ) .Methods Thirty -five AECOPD patients ( AECOPD group ) , 38 COPD patients in statinary phase ( Statinary group ) and 30 healthy aged people control group were selected in this study .The serum leptin, tumor necrosis factor-α(TNF-α) and C-reactive protein (CRP) were detected.Pulmonary function test was taken.The correlation between the serum leptin level and TNF -α, CRP, lung function index were analyzed . Results ①The serum leptin , CRP and TNF-αin AECOPD group were higher significantly than those in Statinary group and Control group .The pulmonary function index -FEVl, MVV and DLCO were lower significantly than those in Statinary group and Control group .②The serum leptin level in patients with COPD had positive correlation with CRP , TNF-α, and had negative correlation with pulmonary function index-FEVl, MVV and DLCO.Conclusion Leptin is a predictor of COPD, and may be useful for assessing risk of impaired lung function .
Keywords：LeptinChronic obstructive pulmonary disease (COPD)Tumor necrosis factor-α(TNF-α)C-reactive protein (CRP)Lung functionAcute exacerabation
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 708-710 )