Effects of respiratory mechanics of different oxygen flow rate to drive inhalation of heparin in mechanically ventilated patients with acute exacerbation of chronic obstructive pulmonary disease
Abstract：Objective To investigate the effects of different oxygen flow rate driven inhalation of heparin on respiratory mechanics in mechanically ventilated patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD ) .Methods Fifty-one patients with AECOPD mechanical ventilation were randomly divided into A , B and C three groups .Group A ( 17 cases ) were given atomizing inhalation with the oxygen flow rate of 5 L/min , group B ( 19 cases ) were given the oxygen flow rate of 7 L/min, group C ( 15 cases ) were given the oxygen flow rate of 9 L/min.Respiratory mechanics were detected before and 30 min, 1, 3 and 7 days after atomizing inhalation in all patients . Results Compared with group A and C , patients in group B had obviously improved peak pressure and platform pressure of airway, airway resistance, the total dynamic pulmonary compliance (P<0.05);but there was no statistical significance between group A and group C (P>0.05).Patients in group B had significantly improved peak pressure and platform pressure of airway , airway resistance , the total dynamic lung compliance at each time point compared with those before atomization ( P <0.05 );patients in group A had significantly changed indexed above mentioned at the time points after 30 min of atomization compared with those before atomization (P<0.05);but there were no significant changes in all time points of group C when compared with before atomization (P>0.05).Conclusion The best oxygen flow rate is 7 L/min for heparin inhalation in mechanically ventilated patients with AECOPD , it can reduce airway pressure and airway resistance and increase the total dynamic pulmonary compliance .
Keywords：Atomization inhalationHeparinChronic obstructive pulmonary diseaseRespiratory mechanics
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 703-707 )