The protective effect of Omega-3 PUFA on patients with sepsis resulting from serious abdominal infection
Abstract：Objective To observe the therapeutic effect of ω-3 polyunsaturated fatty acid (ω-3 PUFA) on patients with sepsis resulting from serious abdominal infection .Methods Fifty-three patients were randomly divided into routine total parenteral nutrition group ( control group , 28 cases) and ω-3 polyunsaturated fatty acid +TPN (study group, 25 cases).All patients received the same basic treatment and TPN with equal nitrogen content and calories , and the ω-3 PUFA 0.2 g/(kg· day) was added to study group lasting 5 days.The activation of NF-κB and the concentrations of serum TNF-α, IL-1, IL-6 and HGMB-1 were detected before and 3, 6 days after the treatment respectively.The length of ICU stay and at 28 days mortality were recorded .Results Compared with the control group, the activation of NF -κB and the concentrations of serum TNF -α, IL-1, IL-6 and HGMB-1 decreased significantly in study group 3, 6 days after the treatment , and the difference was statistically significant (P <0.05).The length of ICU stay was decreased (P <0.05).No statistical difference was found in mortality at 28 days (P>0.05).Conclusion ω-3 PUFA is an effective immunity regulating nutrient that can significantly reduce the serum concentrations of inflammatory response indicators , inflammatory reaction , and length of ICU stay for patients with sepsis resulting from serious abdominal infection .
Keywords：Sepsisω-3 Polyunsaturated fatty acidIntravenous nutritionInflammatory reactionPrognosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 676-678,679 )