Relation ship betweent he levels of serum thyroid hormone and the severity of illnes during th e early phase of sepsis
Abstract：Objective To explore the relationship between the levels of serum thyroid hormones ( TH) and the state of severity during the early phase of sepsis .Methods 103 sepsis patients without thyroidal illness were divided into two groups according to their state of severity:a minor sepsis group of 62 patients and a severe sepsis group of 41 patients .The levels of thyroid hormones ( TT3 ,TT 4 , FT3 , FT 4 and TSH ) , blood lactate and chronic health evaluation Ⅱ( APACHEⅡ) score were compared respectively in all patients on the first day .The correlation of the level of thyroid hormone with the APACHEⅡscore and the blood lactate was analyzed as well .Results There were significant differences between the two groups in the levels of serum TT 3 , TT4 , FT3 , FT4 , blood lactate and APACHEⅡscore (P<0.05 or P<0.01).There was no significant difference in the level of serum TSH between the two groups(P>0.05).The levels of serum FT3 and FT4 were significantly correlated with the APACHEⅡscore in those patients (r=-0.218 and -0.194, P<0.05).There was no relationship in serum TT3, TT4 ,TSH with APACHEⅡscore and blood lactate in these patients .Conclusi on The levels of serum thyroid hormones (especially FT3 and FT4 ) are in correspondence with severity of illness and have an important clinical significance in early phase of sepsis patients .
Keywords：SepsisEarly phaseThyroid hormoneAPACHEⅡscoreBlood lactateRelationship
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 673-675 )