Effects of L-tetrahydropalmatine on nitric oxide and carbon monoxide concentration in plasma during cerebral ischemia reperfusion
Abstract：Objective To observe the effects of L -tetrahydropalmatine(L -THP)on nitric oxide (NO) and carbon monoxide (CO) concentration in plasma during cerebral ischemia reperfusion . Methods Cardiopulmonary resuscitation ( CPR) of 35 cases of postoperative patients were divided into 2 groups in random:treatment group(n=20)and control group(n=15).Two groups of patients after CPR immediately to give general treatment .Treatment group after the onset of the cranial pain .Nitrate reductive enzymatic method was used to detect the serum content of NO; visible spectrophotometer method was used to detect the serum content of CO .Results NO content was elevated at 6, 24, 48, 72 hour, and peaked at 48 hour when cerebral ischemia occurred within 5 minutes;CO content peaked at 6 hour, while peaked at 24 hour when cerebral ischemia occurred within 5 minutes;L-THP significantly increased NO concentrations and reduced CO concentrations after cerebral ischemia reperfusion from 6 to 24 hour, while reduced NO concentrations after cerebral ischemia reperfusion from 24 to 72 hour. Conclusion L-THP probably has a good effect on cerebral ischemia -reperfusion injury by regulating the NO and CO contents .
Keywords：L-tetrahydropalmatineNitric oxideCarbon monoxideCerebral ischemia reperfusion
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 318-322 )