Effects of aer osol inhalation of heparin on arterial blood gas and coagulation function of patients with acute exacerbation of chronic obstructive pulmonary disease by mechanical ventilation
Abstract：Objective To investigate the effects of aerosol inhalation of heparin on arterial blood gas and coagulation function of patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD ) by mechanical ventilation .Methods Patients were collected for the prospective and double -blind clinical intervention . Forty six mechanically ventilated AECOPD patients were randomly divided into two groups .All patients received the same conventional treatment .The patients in the control group (20 cases) inhaled 0.45% saline (10 mL) as placebo; the patients in the heparin group (26 cases) inhaled ordinary heparin (12 500 IU ×4);both groups were single aerosol inhalation . Arterial blood analysis and coagulation function were detected in different timing .Results Compared with the control group , in the heparin group , the arterial blood gas indices of PaO 2 , PaO2/FiO2 , SaO2 with the extension of time were gradually increased (P<0.05).And compared with before atomizated inhalation heparin, PaO2, PaO2/FiO2, SaO2 were gradually increased in 3, 5, 7 days (P<0.05). There was no significant difference of the arterial carbon dioxide tension ( PaCO2 ) before atomization and the first three days in the two groups (P>0.05), but PaCO2 began to significantly increased in each group after 5, 7 days (P <0.05).Prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) were not significantly different between the two groups (P>0.05). Conclusion Atomizated inhalation o heparin for AECOPD patients by mechanical ventilation is safe and effective.It can significantly improve arterial partial pressure of oxygen , reduce carbon dioxide partial pressure, but minimal impact the patient's coagulation function .
Keywords：HeparinChronic obstructive pulmonary disease ( COPD)Atomization inhalationArterial blood analysisCoagulation function
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 314-317 )