Circulating levels of platelet -leukocyte aggregates in patients with sepsis

doi:10.3969/j.issn.1002-1949.2014.04.001

Abstract：@ Objective To investigate circulating levels of platelet -leukocyte aggregates ( PLA) in patients with sepsis .Me thods A total of 100 sepsis patients were enrolled , including 30 sepsis patients, 40 severe sepsis patients and 30 septic shock patients .Circulating levels of platelet -neutrophil aggregates ( PNA ) and platelet -monocyte aggregates ( PMA ) were quantitatively analyzed by flow cytometry.With 28 days as end point, circulating levels of PLA, acute physiology and chronic health evaluation (APACHEⅡ) score and sequential organ failure assessment (SOFA) score were compared with different prognosis respectively .Results Circulating PMA and PNA levels were significantly higher in 100 sepsis patients than those in controls (P<0.01).The rank of circulating PMA and PNA levels in patients was:septic shock patients >severe sepsis patients >sepsis patients >controls, with significant difference among the groups (P<0.01).Compared to the patients with good prognosis (63 cases), circulating PMA and PNA levels , APACHEⅡscore and SOFA score in those with poor prognosis ( 37 cases) were significantly increased (P<0.05).Conclusion PLA levels are increased significantly in patients with sepsis and associated with the severity of sepsis , suggesting that platelet is involved in the pathogenesis of sepsis and PLA indicates the disease process in patients with sepsis .