lnhibition of hepatitis B virus by retroviral vectors expressing antisense RNA
Abstract：Objective Research on the effects of antisense RNA against HBV infection.Methods Retroviral vector expressing antisense RNA complementary to HBVX(1400-1430),P(2375-2405)was used to transduce 2.2.15 cell.We use FQ-PCR methods to test celluar HBV DNA and HBV RNA.Results The results showed that the celluar DNA and RNA in S、C、P ORFs were greatly inhibited.Conclusions The results demonstrated that retroviral vectors containing shorter antisense fragment can inhibit HBV replication and expression.Therefore the antisense RNA may be potentially useful for anti-HBV gene therapy.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 263-265 )