Study of the role of inflammatory cytokines and complement in the pathophysiological process of acute myocardial infarction
Abstract：Objective To study the role of inflammatory cytokines and complement in the pathophysiological process of acute myocardial infarction(AMI).Methods By use of enzyme-linked immunosorbent assay (ELISA),changes serum interleukin-8、tumor necrosis factor-α and composition of complement activation(sC5b-9)levels were measured in 38 AMI and 40 healthy controls.Results The serum interleukin 8、tumor necrosis factor-α and composition of complement activation (sC5b-9)levels were higher in AMI than those in healthy controls (P＜0.01).The levels of cytokines and complement began to recover form 7 days after the AMI but they did not reach the normal level until 28 days after AMI.Conclusions The cytokines and complement participate in the pathophysiology of AMI.The levels of which are correlated with the severity of the disease.The use of anti-inflammatory may be a useful method for treatment of AMI.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 261-262 )