Factors relating to delayed brain disease following acute carbon monoxide poisoning-an experimental study
Abstract：Objective To observe the changes in nitric oxide synthases in brain,endothelium count,platelet volume,the expression of leukocyte adhesion molecules (CD11b/18)in peripheral blood,tPA and PAI in plasma and percentage of apoptotic cells in hippocampus following carbon monoxide poisoning and to evaluate the significance of these factors to delayed brain disease.Methods 48 Wistar adult rats were divided evenly into six groups.Rats were exposed to CO environment (2950 ppm,60 min) except those in the control group.Samples obtained from rats were measured immediately after CO exposure and at 5th，10th，15th and 20th day.A detailed analysis were made by flow cytometry and spectrophotometer.Results In the CO poisoned rats,the platelet activity,the expression of leukocyte adherence molecules and the percentage of apoptotic cells are higher,and the mitochondrial membrane potential of hippocampus neurons are lower than those in the control rats.Fibrinolysis system has a slight change yet.Conclusions The factors observed are involved in cerebral tissue injury in rats after onset of acute carbon monoxide poisoning.They seem to be associated with the occurrence of delayed brain disease.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 253-255 )