Experiment of treatment of Rheum officinal Baill and panax Notoginseng Saponins on MODS induced by fish bile poison
Abstract：Objective To study the pathophysiologic basis of MODS such as internal organic injury,disturbance of microcirculation and oxygen free radical produced eruptively,in experiment animals poisoned by fish bile poison and to study the therapy of Rheum officinal Baill and Panax Notoginseng Saponins on MODS.Methods Make the animal model of MODS,Which is produced by pouring fresh fish bile into stomach.Determine the content of SOD,β2-MG(in serum and urine) in different periods after and before treatment.Observe the pathologic changes of heart,liver,kidney and intestine by microscope and electron.Results Before treatment,SOD in treatment groups and control group all show progressive decrease and after treatment it gradually recovers.β2-MG is just like SOD.The difference (including SOD and β2-MG) between groups treated by Rheum officinal Baill,or Panax Notoginseng Saponins and control group is obvious (P＜0.05).And the difference between groups streated by Rheum offficinal Baill,or panax Notoginseng Saponins and control group is very obvious (P＜0.01).The hearts,livers and intestines all have pathomorphologic changes but have no specificity.The change in treatment groups is less than that in control group.Conclusions Rheum officinal Baill,and panax Notoginseng Saponins have a protective effect on cells and tissues of the heart,liver,kidney and intestine,and on macosa of intestine.The two drags can improve microcirculation and have efficiency of antioxygen free radical as well. The combination of Rheum officinal Baill and panax Notoginseng Saponins is more effcient.It is worth making a further clinical study.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 251-252 )