Laboratory observation of resuscitation by closed chest cardiopulmonary bypass with hypothermia after 15 minutes cardiac arrest in dogs
Abstract：Objective To observe the effects of resuscitation by closed chestcardiopulmonary bypass(CPB) with mild and deep hypothermia after 15 minutes cardiac arrest in dogs.Methods Adult normothermia dogs were submitted to 15 minutes cardiac arrest by potassicum chloride induced cardioplegia. Resuscitation was carried out by CPB with mild hypothermia(33～34℃) in group 1(n=5) and with deep hypothermia in group 2(n=5). After 15 minutes, the body temperature were elevated to normothermia. During resuscitation, ECG, mean arterial blood pressure, centrical venous pressure, intracranial pressure and pupils were monitored.Results Outocirculation returned in group 1 were 5 of 5 (100%) and 3 of 5(60%) in group 2. The returned outocirculation time were (444±192.2)seconds in group 1, significantly faster than (1 980±681.5) seconds in group 2 (P＜0.05). Intracranial pressure in group 1 were (2.4±0.44)cmH2O, significantly lower than (11.2±3.76)cmH2O in group 2(P＜0.05).Conclusion The outocirculation returned by CPB with mild hypothermia more effective than with deep hypothermia after 15 minutes cardiac arrest in dogs.
Machine-generated Keywords：
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 199-201 )