Effect of Batroxobin(DF-521) on intimal proliferation after balloon injury of atherosclerotic iliac arteries in rabbits
Abstract：Objective To study the effect of Batroxobin(DF-521) on intimalproliferation after balloon injury of atherosclerotic iliac arteries in rabbits.Methods Arterial atherosclerosis model was established in rabbits by feeding hypercholesterol diet.18 rabbits were divided into two groups randomly.In treatment group(n=10), Batroxobin 5Bu was taken intravenously 5 hours after endothelial debridement,and then 2.5Bu every other day, for six times.In control group (n=8),no Batroxobin was taken.The rabbits were killed 30 days later.Pathmorphological examination and flow cytometry were carried out.Results ①Batroxobin significantly reduced the thickness of the iliac arterial intima and increased the luminal cross-dectional area of the iliac arterial intima and increased the luminal cross-sectional area of the arteries,compared with the control group (all P＜0.001).②The number of proliferous cells of the arterial wall in the treatment group was significantly lower than that in the control group(all P＜0.001).Conclusion Batroxobin could effectively inhibit the hyperplasia of smooth muscle cells in the arterial intima and significantly reduced intima thickness.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 193-195 )