The clinical study on effect of intracellular glycogen on liver ischemia reperfusion injury

doi:10.3969/j.issn.1002-1949.2001.03.010

Abstract：Objective To study the effect of intracellular glycogen on liver ischemia - reperfusion injury from hepatic vascular exclusion. Methods 17 patients were divided into experiment group( n-- 9)and control group(n = 8). The patients of experiment group were injected with 250 ml of 25% glucose via vein per 6 hours during pre - operative 24 hours. The pathological liver tissue were resected by using portal triad clamping in the two groups. Hepatic tissue were biopsied to measured hepatic tissue ATP contents at the point of pre - ischemia, post - is chemia and reperfusion 1 hour. Furthermore, liver function of all patients were investigated at the point of pre - operative and post - operative 1and 5 days. Results Hepatic tissue ATP contents of experiment group significantly were higher than that of control group at the point of postischemia or repeffusion 1 hour ( P ＜ 0.01) .Besides,liver function of experiment group were significantly better titan that of control group at the postoperative 1 and 5 days ( P ＜ 0.01). On the contrary, there was no difference between the two groups during pre - operation. Conclusion Before liver blood flow is obstructed in order to perform complex liver operation,intracellular abundant glycogen may reduce liver ischemia- repeffusion injury caused by hepatic vascular exclusion.