Clinical research on the chemical and toxic pulmonary edema induced by nitrogen tetroxide

doi:10.3969/j.issn.1002-1949.2001.03.007

Abstract：Objective To investigate the clinical method of the chemical and toxic pulmonary edema induced by nitrogen ox-ide. Methods ①Intermittent and high flux inhalation of oxygen humidified by 50% alcohol; ②Aerosol inhalation of silicon oil to the patientwith significant symptom of lung; ③Intro venous injection of Methylene blue and (or) Vitamine C according to the cyanosis; ④Intro venousinjection of half dosage cedilanid to the patient with high heart rate; ⑤10～ 20 milligram furosemide intro venous injection;⑥The key point iscombine and high dosage using hyoscyamine and dexamethason during the treatment and to apply respirator to the patient those who have respi-ratory failure or hypoxemia. Results There are 19 chemical and toxic pulmonary edema cases among 64 cases intoxication of nitrogen tetroxide3 were dead and 16 was saved of the 19 cases. Conclusion Chemical and toxic pulmonary edema induced by nitrogen oxide was more severethan other type and was difficult to cure .Multiple treatment is tie most important: cardio- pulmonary resuscitation, antifoam agent, ultrasonicaerosol inhalation, antianaphylatic and antalkali treatment, avoid methemoglobinemia and electrolyte disturbance,propedy posture and high fluxinhalation of oxygen. Combine using byoscyamine and dexamethason was effective in the treatment.