Effect of ligustrazine and shenmai injection on myocardial injury in the aged rats with brain ischemia reperfusion

doi:10.3969/j.issn.1002-1949.2001.03.004

Abstract：Objective To study the protective mechanism of Ligustrazine(LT),Shenmai Injection (SI),combination of Ligustrazine and Shenmai injection (LSI) to myocardial injury after brain ischemia reperfusion in aged rats from the changes of Dopamine(DA), Noradrenalin(NE) ,Epinephrine(E),Neuropeptide Y.Methods Aged rats (more than 20 months) were divided into model group(AMG) ,control group(ACG),nimotop group(NG),LT group, SI group and LSI group. The contents of NE, DA, E, NPY, the activity of lactic dehydrogenate (LDH) and creative phosphokinase(CPK) were measured in the rats with brain ischemia. Results Comparing with the ACG' s, the obvious pathological change of myocardium was found in the AMG;the activity of sern CPK and LDH and the content of brain NPY increased,the serum NE and hypothalamus DA content was higher,the hypothalamus NE content was lower. The pathological improved change of myocardium was obvious and the level of brain NPY was lower in the SI's and the LSI's; serum CPK activity in the LT's and the LSI's and serum LDH activity in the LT's and the SI's decreased;the changes in hypothalamus DA content decrease and in hypothalamus NE content increase in the LT's, the SI's, the LSI's were obvious,than the AMG's. Conclusions The myocardial injury induced by ischemia reperfusion in aged rats was correlated with the enhanced excitability of sympathetic - adrenal system, the effect of LT, SI and LSI regulating the abnormal of NE, DA in the central nervous and improving NPY change might be one of mechanismes of preventing and curing myocardial injury.