Influence of Anisodamine on neuronal apoptosts after cerebral ischemia reperfusion in the rats
JIANG Chong-hui
YANG Guangtian
TANG Yan
Abstract：Objective The number of suviving neuron, TUNEL positive neuron, HSPT0 positive neuron and the ultrastructure of the CA1 subfield of hippocampus was detected after the cerebral ischemia repeffusion of rats and the protective effects of anisodamine(Ani) were also observed. Methods Pulsinelli' s method was employed to establish cerebral ischemia - reperfusion animal models. Observing the influence of Ani on the number of surviving neuron,TUNEL positive neuron, HSP70 positive neuron and ultrastructure of the CA1 subfield of hippocampus. Results Ani could induce upregulation of HSP70 expression after cerebral ischemia reperfusion. Neuronal apoptosis after cerebral ischemia reperfusion was decreased and the surviving number of pyramidal celIs in hippocampus CA1 was increased by Ani. Conclusion Ani have a remarkable protection on cerebral ischemia reperfusion damage. Its mechanism may be related with decreasing the neuronal apoptosis.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 131-133 )