Effects of propofol on hemodynamic of acute myocardial ischemia- reperfusion injury

doi:10.3969/j.issn.1002-1949.2001.03.002

Abstract：Objective To evaluate the effects of propofol on hemodynamics of acute myocardial ischemia - repeffusion injury. Methods 18 hybrid dogs were divided randomly into NS group ( Normal Saline , 2ml·kg-1·h-1), HP group(High-dosePropofol, 11.2mg·kg- 1· h - 1 ) and LP group ( Low - dose Propofol, 5.6 mg· kg- 1 · h - 1 ). These dogs were subjected to a 90 - min left anterior descending coronary artery (LAD) occlusion followed by 200 min of reperfusion. Before administration, at 60 - min after administration, at occlusion - 90 min and reperfusion - 60 min, - 120 min, - 180 min, the parameters of hemodynamics was assessed by measurement of HR, MAP, CVP, SVR,PAP, PCWP, PVR and CI. Results The change of HR caused by acute myocardial ischemia- reperfusion injury in HP and LP group was smaller than that in NS group. The values of MAP at occlusion - 90 min decreased 27% compared with the baseline ( P ＜ 0.05). The parameters of pulmonary circulation include PAP, PCWP and PVR increased obviously at occlusion - 90 min and repeffusion - 60 min, - 120 min,- 180 min. At 120 - min and 180 min after repeffusion the values of CI in HP and LP group were similar to the values before occlusion, but significantly higher than those in NS group ( P ＜ 0.05) at the same time. Conclusion Propofol can reduce the changes of HR, and protect the function of systemic circulation, pulmonary circulation and CI during acute myocardial ischemia - repeffusion injury in a canine model.