Effects of acute omethomate poisoning on rats in respiratory failure with treatment
Abstract：Objective The study was designed to examine the mechanism ofrespiratory muscle paralysis by acute omethomate poisoning. Methods Rats were administered in vivo with same doses of omethomate(2LD50) and rats were treated with atropine or atropine plus PAM-CI. The function of isolated rats phrenic diaphragm was observed by MS-302 analyses instrument in physiology and pharmacology. Results In atropine group the function of isolated rats phrenic diaphragm was significantly less than that in control group (P＜0.01). In atropine plus PAM-CI group the function of isolated rats phrenic diaphragm was similar to control group. Conclusion The reason of respiratory muscle paralysis may be related to the unreasonable treatment between atropine and PAM-CI.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 71-72 )