Experiment study on protective effects of naloxone on lung injury from intestinal ischemia-reperfusion
Abstract：Objective To investigate the protective effects of naloxone onlung injury from intestinal ischemia-reperfusion.Methods 32 adult male SD rats were randomly divided into four group (n=8), such as sham-operation, intestinal ischemia-reperfusion( IIR), IIR treated with normal saline (NS control), and IIR treated with naloxone (NX treatent). The plasma levels of β-endophin (β-EP) and levels of malondialdehyde (MDA), myeloperoxidase( MPO) of the lung, as well as pulmonary microvascular permeability were checked in each group. Results The level of β-EP, MDA, MPO and pulmonary microvascular permeability were significantly higher in the group of IIR than sham-operation group. After NX treatment, these parameters of the NX group were significantly lower than NS control group. Conclusion NX showed a protective effects on lung injury from IIR.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 69-70 )