Changes and relationships of the concentrations of β-endorphin and nitric oxide in hemorrhagic shock in rats
Abstract：Objective The purpose of this study is to find if there are somerelationships of plasmic concentration's alteration of β-endorphin(β-EP)and nitric oxide(NO) in hemorrhagic shock(HS) and their mechanisms.Methods 12 Sprague-Dawley rats were anesthetized and subjected to induce HS by femoral arterial catheter.The plasma was collected at five different stages and the concentrations of β-EP,NO and NOS were respectively tested by different biochemical assays.Results The concentrations of β-EP,NO and NOS were all significantly elevated after HS. And the plasmic concentration's alteration of NO was similar to one of β-EP,and was significant positive correlative to one of NOS in late HS.Conclusions ①β-EP and NO may all play important roles in HS;② The enhanced formation of NO in late HS is mainly produced by iNOS.This suggests that iNOS may be a key to the development and the prognosis of HS;③The results also suggest that β-EP and NO may be mediated by one another,and may be in synergy to exert effects in HS.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 66-68 )