Effect of naloxone on the contents of endothelin calcitonin gene-related pepitide and oxygen free radical in the patients with acute cerebral injury
LIANG Min
Liang Ning
BAI Ling-jun
Abstract：Objective To study the effect of naloxone on the plasma contents of endothelin (ET) calcitonin gene-related pepitide (CGRP) and oxygen free radical (OFR) in patients with acute cerebral injury (ACI) during neurosurgery. Methods Plasma ET, CGRP were determined by radioimmunoassay me thod and OFR were by electron spin resonance (ESR) specotroscopy method.Results ET and OFR were signif icantly increased before anesthesia in patients with ACI compared to normal value (all P＜0.01).CGRP level was significantly lower in patients with CHF comp ared to normal value (all P＜0.01). At 120 minutes after neurosurgery ET and OFR were significantly increased (all P＜0.01).Meanwhile, CGRP level was significantly decreased (P＜0.05).After treatment with naloxone, the CGRP level was significantly increased (P＜0.01) and ET, OFR were significantly decr eased (all P＜0.01). Conclusion Therapeutic dose of naloxone may markedly increasing the level of CGRP in vivo and also antagonistic effect on the content of ET. Naloxone may play a role in brain protection and actas an OFR scavenger in vivo.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 24-25 )