Biological features and research progress of the targeted therapy of alveolar soft part sarcoma
ZHANG Li-ming
HUANG Jian-hao
SUOLANG Daji
ZHU Yan
FAN Gen-tao
WANG Yi-cun
ZHOU Guang-xin
Abstract：Alveolar soft part sarcoma (ASPS) is a rare and highly aggressive soft tissue sarcoma resistant to conventional chemotherapy. Although early surgical resection can significantly improve survival rates for patients with ASPS, the prognosis for those with advanced metastatic disease is extremely poor. The malignant characteristics of ASPS include pronounced angiogenesis after the overexpression and activation of angiogenic factors. Therefore, exploration of novel therapeutic approaches is essential. In recent years, molecular targeted therapy has become increasingly important in clinical treatment. A deep understanding of the biological properties and molecular processes of ASPS is crucial for identifying new molecular targets for therapeutic strategies. This review will summarize the biological characteristics of ASPS and the latest advancements in targeted therapy.
Keywords：Sarcomaalveolar soft partMolecular targeted therapyReview
Publication Date：2025-05-19
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 470-475 )