Individualized total femoral and knee prosthesis replacement for undifferentiated pleomorphic sarcoma:one case report
WU Yuan-yuan
SHANG Qi-song
LI Zhe
LU Yun
XIANG Wei
SONG Xing-hua
Abstract：Objective To summarize the etiological mechanism, clinical manifestations, pathological manifestations, diagnostic methods, differential diagnosis and treatment of undifferentiated pleomorphic sarcoma through clinical treatment and related literature analysis, and to provide treatment ideas for clinical diagnosis and treatment. Methods The diagnosis, clinical manifestations, differential diagnosis and treatment of a patient with undifferentiated pleomorphic sarcoma in our department were recorded, and relevant literature was screened and analyzed. Results The male patient was 47 years old, and was diagnosed as undifferentiated pleomorphic sarcoma through preoperative puncture biopsy. After clear diagnosis and evaluation of the patient's condition, one cycle of neoadjuvant chemotherapy was given to the patient, followed by resection of femur bone tumor supplemented with individualized total femur and knee artificial prosthesis replacement, and four cycles of neoadjuvant chemotherapy were given to the patient after surgery. The patient's incision recovered well without any other obvious discomfort. No dislocation or breakage of the prosthesis was seen. Moderate functional exercises were carried out, and the follow-up continued. Conclusions Undifferentiated pleomorphic sarcoma can be treated by artificial prosthesis replacement combined with neoadjuvant chemotherapy, which can control the recurrence and metastasis, helping the patient to recover well.
Keywords：Femoral neoplasmsKnee jointSarcomaProsthesis implantationArthroplastyreplacementkneeUndifferentiated pleomorphic
Publication Date：2025-05-19
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 446-451 )