Research progress of NF-κB signaling pathway in intervertebral disc degeneration
WU Jin-chen
DAI Ji-lu
HAN Wen-yan
ZUO Yuan
Abstract：Low back pain (LBP) is one of the most common health problems, and the leading cause of LBP is intervertebral disc degeneration (IDD). Intervertebral disc degeneration is the consequence of the joint action of factors such as genetics, environment and nutrition, resulting in changes in cell phenotype, inflammatory reactions, increased cell senescence and death, imbalance in the metabolic homeostasis of the extracellular matrix, alterations in the mechanical properties of the nucleus pulposus, and damage to the annulus fibrosus and endplates, eventually developing into intervertebral disc degeneration. Current studies indicate that inflammatory responses play a significant role in intervertebral disc degeneration. A variety of factors can unleash the NF-κB signaling pathway, then accelerate the release of proinflammatory factors, the accumulation of reactive oxygen species, and the degradation of extracellular matrix, causing cellular senescence and finally intervertebral disc degeneration. This article introduces the function, expression and role of NF-κB signaling pathway in intervertebral disc degeneration.
Keywords：Intervertebral disc degenerationNF-kappa BNucleus pulposusReview
Publication Date：2025-01-18
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 83-88 )